Colorectal tumors
1. Big picture
Colorectal tumors mainly means colorectal cancer (CRC), usually adenocarcinoma arising from premalignant adenomas or serrated lesions. It is one of the most important internal medicine tumors because it is common, preventable by screening, often curable when localized, and clinically presents with anemia, bleeding, bowel habit change, or obstruction.
Core exam pattern:
Older patient + change in bowel habit / rectal bleeding / iron-deficiency anemia / weight loss → think colorectal cancer until proven otherwise.
Important clinical split:
| Tumor site | Typical presentation |
|---|---|
| Right-sided colon cancer | Occult bleeding, iron-deficiency anemia, fatigue, weight loss |
| Left-sided colon cancer | Change in bowel habit, constipation, narrowing stool, obstruction |
| Rectal cancer | Hematochezia, tenesmus, urgency, mucus, incomplete evacuation |
Colonoscopy with biopsy confirms diagnosis; staging determines treatment. Colon cancer is usually managed with surgical resection ± adjuvant chemotherapy, while rectal cancer often needs pelvic MRI staging, neoadjuvant chemoradiotherapy or total neoadjuvant therapy, and total mesorectal excision.
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